It is believed that inflammation in MKD is triggered by shortage of isoprenoid lipids and defective prenylation of small GTPases. This pathway is responsible for cholesterol synthesis and the production of isoprenoid lipid tags required for post-translational prenylation of proteins. MKD is caused by recessive, hypomorphic mutations in the mevalonate kinase gene ( MVK) encoding a key enzyme in the mevalonate pathway. Severely disabled applicants are given preference in cases of equal suitability.Īll jobs, all information, all benefits via the apply click button.Introduction: Mevalonate Kinase Deficiency (MKD) is a periodic fever syndrome characterised by recurrent bouts of high fever and systemic inflammation. For this reason, we give priority to hiring women in areas in which women are underrepresented, provided they have the same professional and personal qualifications. 40, 28325 Bremen, Germany.Įqual opportunity and diversity is an important part of our human resources policy.
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